liver fibrosis and noninvasive serum based biomarkers

Serum hyaluronic acid and laminin as biomarkers in liver fibrosis.

BACKGROUND AND AIM Non-invasive methods have been proposed as surrogate markers for liver biopsy. It was shown that serum hyaluronic acid (HA) and laminin (LN) levels increase with the development of liver fibrosis. The aim of this study was to determine serum HA and LN levels cut-off points for predicting liver fibrosis, highlighting their diagnostic value and their changes during treatment. ...

Noninvasive Measures of Liver Fibrosis and Severity of Liver Disease.

Determining the degree of fibrosis is an important step in the assessment of disease severity in patients with chronic liver disease. Liver biopsy has been the gold standard for estimating the extent of inflammation and fibrosis, although the procedure has limitations such as sampling error and variability. Noninvasive testing has been shown to be equally predictive in ruling out fibrosis or ru...

Assessment of Liver Fibrosis: Noninvasive Means

Liver biopsy, owing to its limitations and risks, is an imperfect gold standard for assessing the severity of the most frequent chronic liver diseases chronic hepatitis C (HCV), B (HBV) non alcoholic (NAFLD) and alcoholic (ALD) fatty liver diseases. This review summarizes the advantages and the limits of the available biomarkers of liver fibrosis. Among a total of 2,237 references, a total of 1...

Noninvasive biochemical markers of liver fibrosis.

The assessment of liver fibrosis provides useful information not only for diagnosis but also for therapeutic decision. Although needle biopsy of the liver is the gold standard for fibrosis assessment, it has some technical limitations and risks. This has led to the development of noninvasive biochemical markers of liver fibrosis: direct markers which reflect extracellular matrix turnover and in...

Noninvasive assessment of liver fibrosis. Serum markers and transient elastography (FibroScan).

Both the prognosis and potential treatment of chronic liver disease greatly depend on the progression of liver fibrosis, which is the ultimate outcome of chronic liver damage. Historically, liver biopsy has been instrumental in adequately assessing patients with chronic liver disease. Histological assessment allows clinicians both to obtain diagnostic information and initiate adequate therapy. ...

noninvasive methods to evaluate liver fibrosis in chronic hcv infection